منابع مشابه
Histone exchange program
An integrin’s gut instincts E pithelial β1 integrins are known for their anchoring abilities. But their talents are different in the gut, say Jones et al. (page 505), where cells without β1 integrin stick just fi ne but overproliferate. By anchoring cells to the matrix, β1 integrin probably keeps cells alive and cycling. Indeed, proliferation is promoted, not halted, by this integrin in skin an...
متن کاملHistone chaperones regulate histone exchange during transcription.
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. Th...
متن کاملAnalysis of Histone Exchange during Chromatin Purification.
Central to the study of chromosome biology are techniques that permit the purification of small chromatin sections for analysis of associated DNA and proteins, including histones. Chromatin purification protocols vary greatly in the extent of chemical cross-linking used to prevent protein dissociation/re-association during isolation. Particularly for genome-wide analyses, chromatin purification...
متن کاملRegulation of Reprogramming and Cellular Plasticity through Histone Exchange and Histone Variant Incorporation.
Early embryonic cells are totipotent and can generate a complete organism including embryonic and extraembryonic tissues. After division, cells lose their potency as they move toward a pluripotent state characterized by decreased cellular plasticity. During this transition, drastic changes in transcriptional programs occur in parallel with global chromatin reorganization. The epigenetic mechani...
متن کاملPARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation
Transcriptional activation is accompanied by multiple molecular events that remodel the local chromatin environment in promoter regions. These molecular events are often orchestrated in response to the activation of signalling pathways, as exemplified by the response of immediate early genes such as FOS to ERK MAP kinase signalling. Here, we demonstrate that inducible NFI recruitment permits PA...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1753iti3